Prevalence of hypospadias in grandsons of women exposed to diethylstilbestrol during pregnancy: a multigenerational national cohort study.
نویسندگان
چکیده
Prenatal diethylstilbestrol (DES)-exposed mice have raised the suspicion of a transgenerational effect in the occurrence of genital malformation in males. This nationwide cohort study in collaboration with a French association of DES-exposed women studied 529 families and showed that a significant proportion of boys born to DES daughters exhibited hypospadias with no other molecular defects identified.
منابع مشابه
Organic Food Consumption during Pregnancy and Hypospadias and Cryptorchidism at Birth: The Norwegian Mother and Child Cohort Study (MoBa)
BACKGROUND The etiologies of the male urogenital anomalies hypospadias and cryptorchidism remain unclear. It has been suggested that maternal diet and environmental contaminants may affect the risk of these anomalies via placental or hormonal disturbances. OBJECTIVES We examined associations between organic food consumption during pregnancy and prevalence of hypospadias and cryptorchidism at ...
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Although it is well established that women exposed to diethylstilbestrol in utero have an increased risk of spontaneous abortion, ectopic pregnancy, and preterm delivery, it is not known whether they also have an increased risk of infertility. The authors assessed this question in data from a collaborative follow-up study of the offspring of women who took diethylstilbestrol during pregnancy. I...
متن کاملMaternal Macronutrient and Micronutrient Intakes during Pregnancy and their Associations with BMI for-Age z-Scores at Birth: A Cohort Study in Tehran
Background and Objectives: Maternal dietary intakes during pregnancy play vital roles on fetus growth and birth outcomes. The aim of this study was to investigate relationships between the maternal dietary intakes during pregnancy and body mass index for-age z-scores (BAZ) at birth. Materials & Methods: This cohort study was carried out on 342 pregnant women referring to public health centers...
متن کاملContinued follow-up of pregnancy outcomes in diethylstilbestrol-exposed offspring.
OBJECTIVE To evaluate long-term pregnancy experiences of women exposed to diethylstilbestrol (DES) in utero compared with unexposed women. METHODS This study was based on diethylstilbestrol-exposed daughters, the National Collaborative Diethylstylbistrol Adenosis cohort and the Chicago cohort, and their respective nonexposed comparison groups. Subjects who could be traced were sent a detailed...
متن کاملParental occupational exposure to endocrine disrupting chemicals and male genital malformations: A study in the danish national birth cohort study
BACKGROUND Sex hormones closely regulate development of the male genital organs during fetal life. The hypothesis that xenobiotics may disrupt endogenous hormonal signalling has received considerable scientific attention, but human evidence is scarce. OBJECTIVES We analyse occurrence of hypospadias and cryptorchidism according to maternal and paternal occupational exposure to possible endocri...
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ورودعنوان ژورنال:
- Fertility and sterility
دوره 95 8 شماره
صفحات -
تاریخ انتشار 2011